What Is VDR?
VDR is a gene that encodes a protein that acts as a receptor for vitamin D that regulates bone development and calcium absorption. A variant of the gene (rs2228570, FokI polymorphism) is associated with lower bone mineral density in white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal and temporal pattern of off- and on- occupancy of the VDRE by two components, and is affected through chromosomal sites and binding preferences for specific hormones. Microarray studies of human cells demonstrate that more than 100 genes have an identifiable VDRE within their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online storage facility for data and documents relevant to legal transactions, business or other proceedings that have restrictions on viewing printing, downloading, or viewing. It uses a central server and an extranet connection, which is an Internet connection that has restricted access, to provide controlled access to users at specific times when users can view the data and documents.
Companies and investment banks that are involved in mergers and acquisitions are the most common users of VDRs. VDR. They must be able to share information in a transparent manner with potential investors and buyers. Due diligence procedures can also require a large amount of data. Life science companies also utilize VDRs to keep everything from clinical trial results to HIPAA documentation.